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BASF offers the world's largest portfolio of chemical raw materials for the pharmaceutical industry, ensuring the needs of our partners are always met. Every step of biopharmaceutical manufacturing requires high-quality raw materials delivered through a transparent, sustainable supply chain. BASF Biopharma Ingredients is committed to meeting your requirements for every ingredient we supply to the biologics industry. At BASF, we create excipients that are safe, effective, and convenient for your customers. Whether you’re developing orally disintegrating formulations that require taste-masking or modified release tablets, BASF has ingredients to deliver the precision you need, every time. At BASF, we offer a comprehensive range of cutting-edge solubilization polymers, and have an unparalleled understanding of the corresponding process technologies. BASF offers an unparalleled portfolio of excipients for topical formulations, enabling you with the tools to overcome formulation challenges. With products based on over 150 years of industry experience, BASF is committed to maintaining the highest level of quality across the product spectrum. BASF offers a broad portfolio of chemistries designed to simplify the product development process. Coating polymers are suitable for a variety of oral formulation challenges. BASF's pharma grade lipid-based excipients are manufactured in GMP-compliant facilities with high quality and reliability in mind. Consisting of a broad portfolio of polyethylene glycols (PEGs), BASF's portfolio of ethoxylated polymer-solubilizers is known for its versatility across a myriad of dosage forms. BASF offers a broad portfolio of functional excipients including our pharmaceutical grade polysorbate and sorbitan esters. Povidones, copovidones, and crospovidones are versatile materials that serve as the foundation of oral solid dosage forms. BASF offers a broad portfolio of brand families that are suitable for oral, topical, parenteral, and biologic applications. Coprocessed excipients are combination, all-in-one solutions. Kollicoat® coating polymers are suitable for a variety of oral formulation challenges. Kollicream® pharma grade solvents and emollients are manufactured in GMP-compliant facilities with high quality and reliability in mind. Kollidon® povidones, copovidones, and crospovidones are versatile materials that are most commonly used for solid oral dosage forms. Kolliphor® solubilizers, emulsifiers, co-emulsifiers, and surfactants enable the development of safe and effective formulations. Kollisolv® solubilizers and solvents are suitable for a wide range of applications and processing methodologies. Kolliwax® structuring agents, moisture barriers, and lubricants enable the formulation of various dosage forms. Novata® hard fats are structuring agents and matrix builders. Soluplus® is a novel solubilizer, crystallization inhibitor, and a matrix forming polymer. Explore this collection of resources to learn more about our innovative research and pharma solutions.

Biopharma Formulations: Moving Beyond Polysorbates

Dr. Bijan Zakeri’s webinar will focus on surfactants used in the formulation of biologics which include antibodies, therapeutics proteins, vaccines, and others. Briefly, he will talk about BASF’s biopharma story, the ingredients used for formulating biologics, as well as the current state of the industry and pressing challenges. Furthermore, he will present data on Kolliphor® HS 15 and Kolliphor® ELP that are two surfactants being considered as alternatives to polysorbates for formulating biologics. Bijan will also discuss the future directions of the industry and the path to making fit-for-purpose biopharma ingredients.

Key Learnings:

  • Kolliphor® HS 15 and Kolliphor® ELP are non-ionic surfactants that have prior history of use in FDA-approved parenteral drugs and are being considered as alternatives to polysorbates for formulating biologics.
  • Poloxamer 188 is an established alternative to polysorbates for formulating biologics and has been used for formulating marketed drugs that include antibodies, a fusion protein, therapeutic proteins, peptides, and a gene therapy vector.
  • BASF is increasing its presence and capabilities in the biologics formulation space by providing high quality biopharma ingredients to address unmet industry needs.