Algorithm-based Excipient Selection for Solid Dispersion Development
Drug-polymer miscibility is a fundamental factor in the successful development of amorphous solid dispersions (ASDs) – a widely adopted strategy to enhance the solubility and bioavailability of poorly water-soluble drugs. Inadequate miscibility can lead to phase separation, compromising formulation stability, performance, and ultimately product success. As a result, understanding and accurately predicting drug-polymer miscibility is critical for the rational design, selection of excipients, and long-term stability of ASD formulations.
Explore a practical case study on developing an amorphous solid dispersion (ASD) for a poorly soluble drug using Hot Melt Extrusion (HME). Learn how the digital formulation tool ZoomLab® can streamline polymer selection, predict miscibility, and accelerate data-driven decision-making, ultimately reducing development time and risk.