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BASF offers the world's largest portfolio of chemical raw materials for the pharmaceutical industry, ensuring the needs of our partners are always met. Every step of biopharmaceutical manufacturing requires high-quality raw materials delivered through a transparent, sustainable supply chain. BASF Biopharma Ingredients is committed to meeting your requirements for every ingredient we supply to the biologics industry. At BASF, we create excipients that are safe, effective, and convenient for your customers. Whether you’re developing orally disintegrating formulations that require taste-masking or modified release tablets, BASF has ingredients to deliver the precision you need, every time. At BASF, we offer a comprehensive range of cutting-edge solubilization polymers, and have an unparalleled understanding of the corresponding process technologies. BASF offers an unparalleled portfolio of excipients for topical formulations, enabling you with the tools to overcome formulation challenges. With products based on over 150 years of industry experience, BASF is committed to maintaining the highest level of quality across the product spectrum. BASF offers a broad portfolio of chemistries designed to simplify the product development process. Coating polymers are suitable for a variety of oral formulation challenges. BASF's pharma grade lipid-based excipients are manufactured in GMP-compliant facilities with high quality and reliability in mind. Consisting of a broad portfolio of polyethylene glycols (PEGs), BASF's portfolio of ethoxylated polymer-solubilizers is known for its versatility across a myriad of dosage forms. BASF offers a broad portfolio of functional excipients including our pharmaceutical grade polysorbate and sorbitan esters. Povidones, copovidones, and crospovidones are versatile materials that serve as the foundation of oral solid dosage forms. BASF offers a broad portfolio of brand families that are suitable for oral, topical, parenteral, and biologic applications. Coprocessed excipients are combination, all-in-one solutions. Kollicoat® coating polymers are suitable for a variety of oral formulation challenges. Kollicream® pharma grade solvents and emollients are manufactured in GMP-compliant facilities with high quality and reliability in mind. Kollidon® povidones, copovidones, and crospovidones are versatile materials that are most commonly used for solid oral dosage forms. Kolliphor® solubilizers, emulsifiers, co-emulsifiers, and surfactants enable the development of safe and effective formulations. Kollisolv® solubilizers and solvents are suitable for a wide range of applications and processing methodologies. Kolliwax® structuring agents, moisture barriers, and lubricants enable the formulation of various dosage forms. Novata® hard fats are structuring agents and matrix builders. Soluplus® is a novel solubilizer, crystallization inhibitor, and a matrix forming polymer. Explore this collection of resources to learn more about our innovative research and pharma solutions.

Ensuring Softgel Performance: Formulation approach, strategy and consideration for developing PEG-based softgel products 

Softgels are a versatile single-unit dosage form. The successful development of PEG-based formulations requires an understanding of the manufacturing process, the potential shell/fill interactions and their impact on the product performance. The characteristics and the rational selection of shell and fill excipients are key topics of this event.

PEG is a unique excipient that offers a solution for formulating softgel hydrophilic fills and allows modulation of the fill viscosity that is in favor of good processability. However, careful evaluation is required based on the chemical attributes of the active ingredient to limit the formation of degradant products and ensure product stability during shelf life.

Key Learnings:

  • Fundamentals of softgel processing, formulation design and stability issues
  • Key considerations for developing PEG-based softgels
  • Performance benefits of low aldehyde PEGs
  • Shell formulation approaches to minimize gelatin cross-linking and further increase product shelf-life
  • Formulation challenges and relevant solutions for developing PEG-based fill formulations including case studies
  • Key considerations while using PEGs for developing suspension based formulation
  • Use of PEGs in designing self emulsifying lipid based drug delivery system (LBDDS)
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